2/28/2018 · Environment dominates over host genetics in shaping human gut microbiota. Daphna Rothschild 1,2, Here we examine genotype and microbiome data from 1,046 healthy individuals with several distinct ancestral origins who share a relatively common environment, and demonstrate that the gut microbiome is not significantly associated with genetic ancestry, and that host genetics have a minor role in determining microbiome composition.
Environment dominates over host genetics in shaping human gut microbiota Daphna Rothschild 1,2*, … strate that over 20% of the variance in microbiome ? -diversity can be … use only host genetic and environmental data. These results suggest that microbiome alterations aimed at improving, Factors shaping the human intestinal microbiota range from environmental influences, like smoking and exercise, over dietary patterns and disease to the host’s genetic variation.
In this work it is demonstrated that environment dominates over host genetics in shaping human gut microbiota. Human gut microbiome composition is shaped by multiple factors but the relative contribution of host genetics remains elusive.
3/1/2018 · Here we examine genotype and microbiome data from 1,046 healthy individuals with several distinct ancestral origins who share a relatively common environment, and demonstrate that the gut microbiome is not significantly associated with genetic ancestry, and that host genetics have a minor role in determining microbiome composition.
A later version of this preprint was published as Environment dominates over host genetics in shaping human gut microbiota. Nature. 2018 Mar555(7695):210-215.
Gut flora is shaped by the environment. 14.5 Environment dominates over host genetics in shaping human gut microbiota Rothschild D, Weissbrod O, Barkan E, Kurilshikov A, Korem T, Zeevi D, Costea PI, Godneva A, Kalka IN, Bar N, Species identity dominates over environment in shaping the microbiota of small mammals. … Laboratory studies show that environmental factors, particularly diet, are important, while comparative work emphasises host genetics . Here, we compare the influence of host genetics and the environment on the microbiota of sympatric small mammal species …
3/13/2019 · Laboratory studies show that environmental factors, particularly diet, are important, while comparative work emphasises host genetics . Here, we compare the influence of host genetics and the environment on the microbiota of sympatric small mammal species (mice, voles, shrews) across multiple habitats.
